Fri Aug 26 2022

156 articles - From Friday Aug 19 2022 to Friday Aug 26 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Am J Gastroenterol

Letter to the Editor in Response to ACG Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease.

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Gastroenterology

AGA Clinical Practice Update on the Endoscopic Approach to Recurrent Acute and Chronic Pancreatitis: Expert Review.

BEST PRACTICE ADVICE 8: Celiac plexus block should not be routinely performed for the management of pain due to chronic pancreatitis. The decision to proceed with celiac plexus block in selected patients with debilitating pain in whom other therapeutic measures have failed can be considered on a case-by-case basis, but only after discussion of the unclear outcomes of this intervention and its procedural risks.

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Clinically Significant Metachronous Colorectal Pathology Detected Among Young-onset Colorectal Cancer Survivors: Implications for Post-resection Surveillance Guidelines.

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Gastrointest Endosc

Real-world adherence to the 2020 United States Multi-Society Task Force polypectomy surveillance guidelines: an observational study.

Adoption of the 2020 USMSTF surveillance guidelines remains low at 2 years. Further research into outcomes for patients with LRAs and SSPs may increase guideline adoption.

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Gut

Third Asia-Pacific consensus recommendations on colorectal cancer screening and postpolypectomy surveillance.

Thirteen countries/regions in the Asia-Pacific region were represented in this exercise. International advisors from North America and Europe were invited to participate.

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J Crohns Colitis

European Crohn's and Colitis Guidelines on Sexuality, Fertility, Pregnancy, and Lactation.

Therefore, the management of patients with a wish to conceive and during pregnancy requires specialized counselling and appropriate management including a multidisciplinary approach and close involvement of the prospective parents under a shared decision-making model. This updated consensus paper addresses these issues and is aimed to optimize pre-conceptional, pregnancy and post pregnancy counselling, including the monitoring and therapeutic management of patients with IBD patients with a wish to conceive.

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Meta-analysis

meta-analyses and systematic reviews

J Crohns Colitis

Systematic Review and Meta-analysis of Peripheral Blood DNA methylation studies in Inflammatory Bowel Disease.

Methodological homogenization of IBD epigenetic studies is needed to allow for easier aggregation and independent validation. Nonetheless, we were capable of confirming previous observations. Our results can serve as the basis for future IBD epigenetic biomarker research in PBL.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Natural history and impact of irritable bowel syndrome-type symptoms in inflammatory bowel disease during 6years of longitudinal follow-up.

IBS-type symptoms affected more than two-thirds of patients with IBD during >6years of follow-up and were associated with increased healthcare utilisation, and worse anxiety, depression, somatoform symptom and quality of life scores, but not adverse disease activity outcomes.

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Terlipressin use and respiratory failure in patients with hepatorenal syndrome type 1 and severe acute-on-chronic liver failure.

Terlipressin should be used with caution in patients with HRS1 and grade 3 ACLF. Patients with hypoxaemia are at increased risk of RF and mortality.

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Use of statins after liver transplantation is associated with improved survival: results of a nationwide study.

Statin use by LT recipients may confer a survival advantage. Statin administration should be encouraged in LT recipients when clinically indicated.

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Am J Gastroenterol

Artificial intelligence- aided colonoscopy does not increase adenoma detection rate in routine clinical practice.

The ADR and PDR in the AIAC group was lower compared to pre-AIAC (30.3% vs 35.2%, p <0.001; 36.5 % vs 40.9%, p=0.004,respectively); procedure time was significantly shorter in AIAC. In summary, introduction of AIAC did not result in performance improvement in our large-center cohort, raising important questions on AI-human interactions in medicine.

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FLIP Panometry helps identify clinically relevant esophagogastric junction outflow obstruction per Chicago Classification v4.0.

FLIP Panometry provides a useful complement to clarify the clinical significance of an HRM/CCv4.0 EGJOO diagnosis and help direct management decisions.

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Gastric Peroral Endoscopic Pyloromyotomy for Infants with Congenital Hypertrophic Pyloric Stenosis.

G-POEM is feasible, safe and effective for infants with CHPS, with satisfactory clinical responses over short-term follow-up. Further multicenter studies should be performed to compare the long-term outcomes of this minimally invasive technique to open or laparoscopic pyloromyotomy.

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The Ongoing Debate of Serum Ammonia Levels in Cirrhosis: The Good, The Bad, and The Ugly.

In this scenario, other etiologies of altered mental status should be explored. Future research should focus on developing a standardized approach to serum ammonia collection, processing and interpretation.

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Clin Gastroenterol Hepatol

Effectiveness of switching from intravenous to subcutaneous infliximab in patients with inflammatory bowel diseases: the REMSWITCH study.

Switching from intravenous to subcutaneous infliximab 120 mg eow is safe and well-accepted leading to a low risk of relapse in IBD patients except for those receiving 10mg/kg/4weeks requiring 240 mg eow.

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Endoscopy

Minimal water exchange by the air-water valve versus left water exchange in unsedated colonoscopy: a randomized controlled trial.

Compared to LWE, MWE demonstrated a non-inferior outcome for insertion pain, and comparable cecal intubation time and ADR, but reduced the volume of water used and eliminated the need for a water pump.

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Gastroenterology

Comparison of Anorectal Manometry, Rectal Balloon Expulsion Test, and Defecography for Diagnosing Defecatory Disorders.

HR-ARM, BET, and defecography findings were concordant for constipated patients, and reduced rectoanal gradient was the best HR-ARM predictor of prolonged BET or reduced rectal evacuation. Prolonged BET, reduced gradient, and incomplete evacuation each independently supported a diagnosis of DD in constipated patients. We propose the terms probable DD for patients with an isolated abnormal gradient or BET and definite DD for patients with abnormal results from both tests.

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Enterohepatic shunt-driven cholemia predisposes to liver cancer.

PSS is relatively common in C57BL/6 mice and causes silent cholemia, which predisposes to liver injury and HCC, particularly when fed a fermentable fiber-enriched diet. Incidence of silent PSS/cholemia in humans awaits investigation. Regardless, measure of serum BA may aid HCC risk assessment, potentially alerting select individuals to consider dietary or BA interventions.

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Quantitative pathologic analysis of digitized images of colorectal carcinoma improves prediction of recurrence free survival.

QuantCRC provides a powerful adjunct to routine pathologic reporting of CRC. A prognostic model using QuantCRC improves prediction of RFS.

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Gastrointest Endosc

A novel deep learning-based computer-aided diagnosis system for predicting inflammatory activity in ulcerative colitis.

We established a novel deep-learning based scoring system to evaluate endoscopic images from patients with UC, which can also accurately describe the severity and distribution of inflammatory activity through full-length intestinal endoscopic videos.

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Identification of patients with malignant biliary strictures using a cholangioscopy-based deep learning artificial intelligence (with video).

This study demonstrates that a CNN developed using cholangioscopy data alone has greater accuracy for biliary stricture classification than traditional ERCP-based sampling techniques.

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Identification of Visible Lesions During Surveillance Endoscopy for Barrett's Esophagus: A Video-Based Survey Study.

Despite improved endoscope resolution and availability of virtual chromoendoscopy, the overall rate of VL detection remains low. Identification of VLs using NBI may be volume dependent. Further education and training efforts focused on VL detection during Barrett's surveillance endoscopy are needed.

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Gut

Distinct blood protein profiles associated with the risk of short-term and mid/long-term clinical relapse in patients with Crohn's disease stopping infliximab: when the remission state hides different types of residual disease activity.

We identified distinct blood protein profiles associated with the risk of short-term and mid/long-term clinical relapse in patients with CD stopping infliximab. These findings constitute an advance for the development of non-invasive biomarkers guiding the decision of anti-TNFa withdrawal.

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Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment.

Epithelial SOX9 is critical in suppressing CD8 + T cell responses and modified macrophage function in GAC through the paracrine LIF factor. Cotargeting LIF/LIFR and CSF1R has great potential in targeting SOX9-mediated cancer stemness, T cell immunosuppression and metastases suggesting the novel combination therapy against advanced GAC.

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Human gut microbiota after bariatric surgery alters intestinal morphology and glucose absorption in mice independently of obesity.

Exposure of rodents to human gut microbiota after restrictive or malabsorptive bariatric surgery improves glycaemic control. The gut microbiota after bariatric surgery is a standalone factor that alters upper gut intestinal morphology and lowers Sglt1-mediated intestinal glucose absorption, which improves blood glucose control independently from changes in obesity, insulin or insulin resistance.

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Targeted intervention to achieve waste reduction in gastrointestinal endoscopy.

In this interventional study, applying sustainability measures to a real-world scenario, RMW reduction and daily recycling were achieved and sustained over time, without compromising endoscopy productivity.

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Hepatology

AIF1+ CSF1R+ MSCs, induced by TNF-a, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis.

Together, our results show that MSCs which are mobilized to the injured site can be educated by macrophages. In turn, the educated MSCs are involved in generating a chronic inflammatory microenvironment and promoting hepatocarcinogenesis.

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Body weight changes and duration of estrogen exposure modulate the evolution of hepatocellular adenomas after contraception discontinuation.

Weight variation is strongly associated with radiological evolution after oral contraception discontinuation. A score of estrogen exposure, easily assessable in clinical practice at diagnosis, predicts regression of HCA.

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FGFR1/Klothoß agonist BFKB8488A improves lipids and liver health markers in patients with diabetes or NAFLD: a phase 1b randomized trial.

BFKB8488A was adequately tolerated in patients with T2DM or NAFLD, leading to triglyceride reduction, HDL improvements, and trends in improvement in markers of liver health for both populations, and marked liver fat reduction in patients with NAFLD. (ClinicalTrials.gov NCT03060538).

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Genetic predisposition to porto-sinusoidal vascular disorder: a functional genomic-based, multi-generational family study.

Aberrant FCHSD1 structure and function leads to mTOR pathway overactivation and may cause PSVD.

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Janus Kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis.

This study demonstrates that the JAK2 inhibitor pacritinib may be promising for the treatment of alcoholic and non-alcoholic liver fibrosis, and may be therefore relevant for human pathology.

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Non-selective Beta Blockers, Hepatic Decompensation and Mortality in Cirrhosis: A National Cohort Study.

There is an ongoing need to noninvasively identify patients who may benefit from NSBBs for the prevention of hepatic decompensation.

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Performance of AGA Clinical Care Pathway for the Risk Stratification of Patients with Nonalcoholic Fatty Liver Disease in the US population.

The implementation of the current AGA clinical pathway would lead to overutilization of VCTE. An alternative strategy using FIB-4=1.3 and diabetes to select adults undergoing second-line testing will improve this pathway's performance and minimize unnecessary VCTEs.

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Inflamm Bowel Dis

Fusobacterium nucleatum Extracellular Vesicles Promote Experimental Colitis by Modulating Autophagy via the miR-574-5p/CARD3 Axis.

Here, we describe a new mechanism by which Fn-EVs mediate experimental colitis severity through miR-574-5p/CARD3-dependent autophagy activation, providing a novel target for UC monitoring and targeted therapy.

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Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD.

The frequency and severity of symptoms after a third mRNA vaccine dose are generally similar or milder than after a second dose for most organ systems.

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Transcriptional Behavior of Regulatory T Cells Predicts IBD Patient Responses to Vedolizumab Therapy.

Mucosal and peripheral blood immune cell phenotypes and transcriptional profiles can inform VDZ efficacy and inform new opportunities for combination therapies.

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Vaccination Against Measles, Mumps, Rubella and Incident Inflammatory Bowel Disease in a National Cohort of Privately Insured Children.

MMR is associated with decreased risk for childhood IBD.

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Young Adult Male Patients With Childhood-onset IBD Have Increased Risks of Compromised Cortical and Trabecular Bone Microstructures.

Young adult men with childhood-onset IBD are at increased risk of having reduced bone quality in both the cortical and trabecular bone structures compared with normative matched controls.

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J Crohns Colitis

Corticosteroid-sparing Effects of Filgotinib in Moderate to Severely Active Ulcerative Colitis: Data from the Phase 2b/3 SELECTION Study.

Filgotinib 200 mg demonstrated corticosteroid-sparing effects and maintained corticosteroid-free clinical remission in patients with UC. MAIC results should be interpreted cautiously given the large CIs and differences in study design and patient populations.

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GAS6 from CD200 + adipose-derived stem cells mitigates colonic inflammation via a macrophage-dependent manner.

This study uncovered the heterogeneity in ADSCs, in which CD200 + ADSCs presents as an alternative to conventional treatment of IBD.

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NOD2 in Crohn's disease- unfinished business.

The genomics of NOD2 has much that remains unknown, including the role of rare variation, phasing of variants across the haplotype block and the role of variation in the NOD2-regulatory regions. Here, we discuss the evidence and the unmet needs of NOD2-research, based on recently published evidence, and suggest methods that may meet these requirements.

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Safety and Efficacy of an AIEC-targeted Bacteriophage Cocktail in a Mice Colitis Model.

Collectively, the data support the approach of AIEC-targeted phage therapy as safe and effective treatment for reducing AIEC levels in the gut of IBD patients.

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Time to endorse a sensitive method for scoring endoscopic activity of ulcerative colitis in clinical research.

Further, in a post-hoc analysis, we re-examined endoscopic videos from a clinical trial and demonstrate that assessing involved ulcerated and affected areas on a segmental level of the colon or summing Mayo scores of colonic segments can identify improvements in endoscopic disease activity in almost twice as many subjects as identified by the Mayo endoscopic subscore alone. Although the alternative scoring systems we have used in this report will need further validation, our findings demonstrate the need for a more sensitive endoscopic scoring system in ulcerative colitis.

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J Hepatol

Applying an equity lens to liver health and research in Europe.

We report that only 10.2% of studies were led by European institutions or conducted in European populations and that certain topics such as alcohol-related liver disease are largely overlooked. In addition, we discuss the relevance of including a health equity lens in conducting clinical, epidemiological and health systems' research in liver disease and set out the basic requirements to tackle health inequalities in liver disease in Europe.

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Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL6 trans-signaling.

Our results demonstrate that cHCC-CCA, but not HCC tumors, originate from HPCs, and that IL6, which derives in part from cells in senescence, plays an important role in this process via IL6 trans-signaling. These findings could enhance new therapeutic approaches for cHCC-CCA liver cancer.

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Entecavir plus Biejia-Ruangan compound reduces the risk of hepatocellular carcinoma in Chinese patients with chronic hepatitis B.

ETV plus BRC combination treatment could further reduce the risk of HCC and liver-related deaths in CHB patients with advanced fibrosis or cirrhosis, which may have important clinical implications for HCC prevention.

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Hepatectomy-induced apoptotic extracellular vesicles stimulate neutrophils to secrete regenerative growth factors.

These data suggest that the clearance of PHx-induced aEVs leads to a population of non-inflammatory, but regenerative neutrophils, which may support human liver regeneration.

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Impact of the COVID-19 pandemic on liver disease-related mortality rates in the United States.

ASMR for ALD and NAFLD increased at an alarming rate during the COVID-19 pandemic with the largest disparities among the young, non-Hispanic White, and Alaska Indian/Native American populations.

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Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease.

Humans with non-alcoholic fatty liver disease feature distinct abnormalities of VAT energy metabolism, which correlate with adipose tissue dysfunction and may favor progression of NAFL to NASH.

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MRG15 aggravates non-alcoholic steaohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM.

Collectively, these findings uncover a mitochondrial MRG15-TUFM regulation pathway that contributes significantly to the liver progression from simple steatosis to NASH, and a potential target to treat NASH.

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Nestin as a diagnostic and prognostic marker for combined hepatocellular-cholangiocarcinoma.

We show in different clinical settings that Nestin has a diagnostic value and that it is a useful biomarker to identify the subset of cHCC-CCA associated with the worst clinical outcome. Nestin immunohistochemistry may be used to refine risk stratification and improve treatment allocation for patients with this highly aggressive malignancy.

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Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction.

This study provides evidence of compromised brain health in obesity and NAFLD, emphasising the importance of the liver-brain axis. The observation of the protective effect of MCT1 haploinsufficiency points to this protein as a novel therapeutic target for preventing and/or treating NAFLD and the associated brain dysfunction.

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Secretin alleviates biliary and liver injury during late-stage primary biliary cholangitis via restoration of secretory processes.

Loss of Sct/SR signaling in late-stage PBC results in a faulty 'bicarbonate umbrella' and reduced Agr2-mediated mucin production. Sct restores cholangiocyte secretory processes and DCJ formation through enhanced mature cholangiocyte phenotypes and bile duct growth. Sct treatment may be therapeutic for late-stage PBC patients.

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Neurogastroenterol Motil

High-resolution impedance manometry for comparing bolus transit between patients with non-obstructive dysphagia and asymptomatic controls.

The VII ratio was more reliable than the EII ratio for describing bolus transit and distinguishing patients with NOD from asymptomatic controls, even during repeated measures of subsequent swallows.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: earning potential in paediatric-onset IBD-a complex interplay.

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Editorial: IBD and the risk of dementia - the jury is still out.

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Editorial: investigating the association between sweetened beverages and risk of inflammatory bowel disease.

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Editorial: slow progress to optimising H. pylori eradication treatment with antisecretory drugs.

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Editorial: switching to tenofovir alafenamide monotherapy is effective and safe for other nucleos(t)ide analogues-treated patients with chronic hepatitis B.

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Editorial: thiopurines in the multidrug era-time to rescue our memories over half a century of experience.

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Editorial: tripartite motif 26 inhibits hepatitis B virus replication and its genetic polymorphism predicts response to interferon treatment-towards a better understanding of interferon responsiveness in chronic hepatitis B.

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Extrahepatic morbidities and mortality of NAFLD: an umbrella review of meta-analyses.

Patients with NAFLD are at heightened risk of extrahepatic outcomes. However, the certainty of evidence is only from very low to moderate. Further studies at low risk of bias are required to support the evidence and elucidate any causal associations.

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Review article: guide to tofacitinib dosing in patients with ulcerative colitis.

Clinicians must consider the benefit/risk balance of tofacitinib 10 versus 5 mg b.d. in terms of dose-related side effects, as well as the safety implications of undertreating active disease. All patients should be closely monitored for disease relapse following dose reduction or interruption for early recapture of response.

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Gastroenterology

In Memoriam-Helen J. Cooke (1943-2021).

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Gastrointest Endosc

"Fast and furious": Endoscopic gastrojejunostomy revision for treatment of dumping syndrome?

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Artificial intelligence: an innovative approach to prognisticate the outcome of colonic resection.

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Hepatology

Health Disparities in Chronic Liver Disease.

Herein, we review the existing literature on racial and ethnic, gender, and socioeconomic disparities in chronic liver diseases using a social determinants of health framework to better understand how social and structural factors cause health disparities and affect chronic liver disease outcomes. We also propose potential solutions to eliminate disparities, outlining health-policy, health-system, community, and individual solutions to promote equity and improve health outcomes.

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The Liver Cancer Immune Microenvironment: Therapeutic Implications for Hepatocellular Carcinoma.

Other immune targeting-strategies, such as adoptive T-cell transfer, vaccination, or virotherapy, are currently under development. This review provides an overview on the HCC immune microenvironment, the different cellular players, the current available immunotherapies, and potential immunotherapy modalities.

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J Hepatol

Interventional radiology meets immuno-oncology for hepatocellular carcinoma.

We summarize results from recent studies and provide an overview of ongoing studies in IR and IO. Based on the significant advances in both areas, we propose that IR and IO need to cover the emerging "discipline" of IR-IO, in which we develop and test novel approaches to combine locoregional therapies with immunotherapy, in order to eventually develop sufficient evidence for them to be considered standard of care option for HCC patients in the near future.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: investigating the association between sweetened beverages and risk of inflammatory bowel disease-authors' reply.

Pubmed   Journal   ReadQx 

Editorial: potassium-competitive acid blockers-is there a role for more complete acid suppression?

Pubmed   Journal   ReadQx 

Editorial: potassium competitive acid blockers-is there a role for more complete acid suppression? Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: slow progress to optimising H. pylori eradication treatment with antisecretory drugs-authors' reply.

Pubmed   Journal   ReadQx 

Editorial: switching to tenofovir alafenamide monotherapy is effective and safe for other nucleos(t)ide analogues-treated patients with chronic hepatitis B - author's reply.

Pubmed   Journal   ReadQx 

Editorial: thiopurines in the multidrug era-time to rescue our memories over half a century of experience. Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: tripartite motif 26 inhibits hepatitis B virus replication and its genetic polymorphism predicts response to interferon treatment-towards a better understanding of interferon responsiveness in chronic hepatitis B. Authors' reply.

Pubmed   Journal   ReadQx 

Letter: comparison of clinical prediction rules for ruling out cirrhosis in non-alcoholic fatty liver disease (NAFLD).

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Clin Gastroenterol Hepatol

Distinct relapse patterns between HBeAg-negative patients stopping tenofovir and entecavir.

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TIPS in patients with Hepatocellular carcinoma, is there an indication?

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Gastrointest Endosc

Giant cell reaction subsequent to ORISE gel lifting agent captured on endoscopic ultrasound.

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More prognostic information may be harvested in the subgroup analysis of esophageal adenocarcinoma unrelated death.

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New duodenoscope designs: not what we had hoped for.

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Gut

Comparative effects of non-alcoholic fatty liver disease and metabolic dysfunction-associated fatty liver disease on risk of incident cardiovascular events: a meta-analysis of about 13 million individuals.

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Single-cell gene expression links SARS-CoV-2 infection and gut serotonin.

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Unravelling the risk of developing gastric cancer in autoimmune gastritis.

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J Hepatol

Accuracy of Transient Elastography in Assessing Fibrosis at Diagnosis in Patients with Autoimmune Liver Disease.

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Ammonia - an old friend with a new area of application.

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Associations of muscle mass and grip strength with severe NAFLD: a prospective study of 333,295 UK Biobank participants - authors' reply.

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ATG7 genetic variants behave as fatty liver disease progression modifiers.

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Defining endpoints that guide treatment in autoimmune hepatitis.

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Depiction of alcohol-related liver disease in the EASL International Liver Congress.

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Liver stiffness, fatty liver disease and atrial fibrillation in the rotterdam study: some issues - authors' response.

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New terms for fatty liver disease other than MAFLD: Time for a reality check.

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Non-invasive tests for evaluating treatment response in NAFLD.

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Peripheral blood CD177+ cells as an early diagnostic marker for biliary atresia: a prospective multicentre study in pediatric patients with cholestasis.

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Relationship between non-alcoholic fatty liver disease and atrial fibrillation: assessment of latest evidence.

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Reply to three letters.

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Reply to: "an individualized cirrhosis screening strategy might be more cost-effective in the general population".

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SEAL: why was this approach not effective?

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Others

all remaining publications eg case reports, images of the month, etc…

Am J Gastroenterol

A Rare Complication: Post-operative Pyoderma Gangrenosum in Segmental Colitis Associated with Diverticulosis.

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ENDOSCOPIC RESECTION OF AN EARLY-STAGE GASTRIC MELANOMA.

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How I Approach It: Adrenal Insufficiency in Cirrhosis.

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Rectal polyp on extrinsic compression due to prostatic stromal tumor.

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Clin Gastroenterol Hepatol

Development and Validation of the Houston-BEST, a Barrett's Esophagus Risk Prediction Model Adaptable to Electronic Health Records.

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Heightened Risk for Gastric Cancer Among Immigrant Populations in New York State from High-Incidence Countries.

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Endoscopy

A simple endoscopic treatment for large gastric bezoars: the guidewire and snare method.

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Antegrade balloon dilation of the minor duodenal papilla to facilitate serial pancreatic juice aspiration cytology.

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Author commentary on Madhav Desai et al.

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Author commentary on Radhika Chavan et al.

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Challenging full-thickness resection of post endoscopic mucosectomy residual scar in right colon, accessed via a balloon-dilated stoma.

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Clinical response in the haustra-like folds observed during peroral cholangioscopy following steroid therapy for immune checkpoint inhibitor-induced cholangitis.

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Diagnostic esophagogastroduodenoscopy performed using a novel sterile single-use disposable endoscope.

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Different methods of traction employed during endoscopic submucosal dissection of early cancers.

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Efficacy of a gel injected using an endoscopic water jet for visualization of active bleeding during esophageal endoscopic submucosal dissection.

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Endoscopic extraction of migrated gastric bypass Fobi ring in patient after gastric bypass.

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Endoscopic full-thickness resection of IgG4-related gastric submucosal tumor-like lesion.

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Endoscopic salvage extraction of a fish bone impacted in a liver abscess by extra-anatomic cholangioscopy.

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Endoscopic submucosal dissection of an ileocecal valve laterally spreading tumor using an adaptable magnetic traction system.

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Endoscopic submucosal dissection with a novel traction wire for esophageal cancer in the cervical esophagus.

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Endoscopic ultrasonography-guided bilateral drainage with antegrade stenting in patient with malignant hilar biliary obstruction after bowel reconstruction.

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Endoscopic ultrasound-guided portal pressure gradient measurement.

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Expanding rather than closing the wound can rescue the endoscopic procedure when massive bleeding occurs during endoscopic submucosal dissection.

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Gastric peroral endoscopic myotomy for the resection of a predominantly extraluminal submucosal tumor in the duodenal bulb.

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Gel immersion endoscopic mucosal resection for a gastric neoplasm with a background of fundic gland polyposis.

Pubmed   Journal   ReadQx 

Giant Brunner's gland hamartoma of the duodenal bulb removed by endoscopic submucosal dissection.

Pubmed   Journal   ReadQx 

Hemosuccus pancreaticus: an in-motion endoscopic ultrasound view.

Pubmed   Journal   ReadQx 

Iatrogenic colonic perforation closure with an over-the-scope clip applied with a gastroscope 4 hours after index colonoscopy.

Pubmed   Journal   ReadQx 

Long-term transmural plastic stenting after metal stent removal in disconnected pancreatic duct: is the debate over?

Pubmed   Journal   ReadQx 

Management of afferent loop obstruction using multiple single-pigtail plastic stents in a patient with recurrent metastatic pancreatic cancer.

Pubmed   Journal   ReadQx 

Managing perforations during endoscopic resection of gastrointestinal lesions.

Pubmed   Journal   ReadQx 

Modified endoscopic vacuum therapy for hypopharyngeal acute leakage after foreign body perforation.

Pubmed   Journal   ReadQx 

Multipolar traction with adjustable force increases procedure speed during endoscopic submucosal dissection: the A-TRACT-4 traction device.

Pubmed   Journal   ReadQx 

Novel technique for treating simple hepatic cysts: endoscopic transgastric hepatic cyst deroofing.

Pubmed   Journal   ReadQx 

Pyloric ring section with a papillotomy knife for removing an ingested plastic bag closure penetrating the pyloric ring.

Pubmed   Journal   ReadQx 

Reply to Rana and Gupta.

Pubmed   Journal   ReadQx 

Saline-immersion therapeutic endoscopy facilitated en bloc endoscopic submucosal-subserosal dissection of a sigmoid diverticulum containing a refractory adenomatous lesion.

Pubmed   Journal   ReadQx 

Successful detection of choledochojejunal and pancreaticojejunal anastomotic strictures using a novel form of texture and color enhancement imaging.

Pubmed   Journal   ReadQx 

The combination needle injection-incision technique using the two-in-one needle-snare device for knife-assisted resection.

Pubmed   Journal   ReadQx 

Underwater endoscopic mucosal resection of colon hemangiomas compatible with the blue rubber bleb nevus syndrome, following endoscopic ultrasonography.

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Usefulness of a forward-viewing echoendoscope in endoscopic ultrasound-guided recanalization for complete obstruction of the esophagus after chemoradiotherapy for esophageal cancer.

Pubmed   Journal   ReadQx 

Gastroenterology

A 41-year-old man with an abdominal mass and hepatomegaly.

Pubmed   Journal   ReadQx 

ALDH1A1 Expression is Enriched in Early Onset Colorectal Cancers.

Pubmed   Journal   ReadQx 

Clinical image : An unusual cause of anal pain.

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COVID-19 PANDEMIC-RELATED COLORECTAL CANCER SCREENING DELAYS IMPACT UNSCREENED OLDER ADULTS THE MOST, BUT MITIGATION STRATEGIES EXIST.

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Summary Gastro Digest Cancer risk following bariatric surgery.

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Gastrointest Endosc

A long curved appendix.

Pubmed   Journal   ReadQx 

Organizing effective bowel preparation in the endoscopy unit.

Pubmed   Journal   ReadQx 

Technological imbalance: Seeking a small-caliber duodenoscope.

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Hepatology

Attacking the Public Health Crisis of Hepatocellular Carcinoma at its Roots.

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Inflamm Bowel Dis

Editorial: Racial Difference in Efficacy of Golimumab in Ulcerative Colitis.

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The Role of Appendicectomy in Ulcerative Colitis: True or Coincidental Association?

Pubmed   Journal   ReadQx 

Vaccinations for Patients With Inflammatory Bowel Disease in Primary Care: An Opportunity for Improvement.

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J Crohns Colitis

Corrigendum to: P169 Vitamin D levels are inversely associated with inflammation in pediatric Inflammatory Bowel Disease patients.

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Numbers Do Not Lie: The Dire Need for New Directions in IBD.

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J Hepatol

From the Editor's Desk….

Pubmed   Journal   ReadQx   PMC

Hepatopathology of flaviviruses.

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